Santa Cruz was a town mentioned in For a Few Dollars More. When Manco infiltrated in the gang, El Indio's plan was to send four men (Blackie, Paco, Chico and also Manco) to Santa Cruz. He also mentioned fleeing there after robbing the bank at El Paso, so during the robbery Manco killed the other three men, and then told the telegram office's clerk there was a bank rob there, to send El Paso's deputies to Santa Cruz. While at first this resulted in the success of the robbery at El Paso, Manco's intention was to get the gang arrested on their arrival to Santa Cruz. However, Indio was aware that Manco was a bounty hunter, so he decided to go to Agua Caliente instead.

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